Sinthrome Acenocoumarol, as the name suggests, is a tablet created using an active ingredient called acenocoumarol. This tablet is basically an anticoagulant medicine, developed to stop the blood clots formation within the blood vessels.
What is it used for?
The cases wherein blood clots in the blood vessels can be prevented and treated, include the following:
How does it work?
Sinthrome tablet- an oral anticoagulant containing acenocoumarol as an active ingredient stops the formation of blood clots within the blood vessels.
The formation of blood clots is normal in case of any tissue injury. In such case, blood clots are formed to stop the bleeding. This is when body naturally repairs itself. In the clotting process, platelets (blood cells) clump together at the site of injury and produce chemicals that speedily activate clotting factor in the blood. The clotting factor is a combination of two or more proteins produced by liver. Vitamin K has an essential role in the production. The activated clotting factors convert a protein called fibrinogen into protein called fibrin. This converted protein binds the platelets together, forming a blood clot.
The abnormal formation of blood clots within the blood vessels can be dangerous. This situation is termed as thrombus. This can be harmful, because there is a possibility that clot may detach and travel in the bloodstream, where it becomes an embolus. This can cause thromboembolism, a situation where blood clots block the blood supply to vital organ, like heart, brain or lungs.
This medication is recommended for people having an increased tendency of formation of blood clots within the blood vessels. By taking acenocoumarol, this risk can be reduced to minimum.
This tablet prevents the production of clotting factors that are dependent on vitamin K. Inhibiting the clotting factors, the conversion process of fibrinogen into fibrin is stopped. This limits the chances of formation of blood clots to minimum.
The time acenocoumarol takes to generate a complete anticoagulant effect is about three days, as besides preventing production of new clotting factors, it works in already produced clotting factors. That's why, for the treatment of deep vein thrombosis (DTV) or pulmonary embolism, a faster acting injectable anticoagulant, like heparin is often used in the beginning. Acenocoumarol's anticoagulant effect can be measured by the prothombin time, that is when blood clot occurs in a blood sample to which calcium and a substance known as thromboplastin have been added. The term that expresses the time is INR- International Normalised Ratio. A doctor takes blood samples and adjust acenocoumarol dose to make your INR fall into the range effective at preventing blood clots in pateint's particular condition.
How do I take it?
Use with caution in
Not to be used in
People who are allergic to any of the ingredients of this medicine must not take this medicine. Patients who have experienced any kind of allergy must stop using this medicine and immediately inform their doctor or pharmacist.
The effect of medicines and their possible side effects may vary with individual person. Some of the side effects associated with this medicine are as follows:
Rare (affect between 1 in 1000 and 1 in 10,000 people)
Very rare (affect fewer than 1 in 10,000 people)
Anticoagulant agent: Vitamin K antagonist
2H-1-Benzopyran-2-one, 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]- (USAN)